Calcinosis in dermatomyositis treated with probenecid

Scand J Rheumatol. 1981;10(2):92-4. doi: 10.3109/03009748109095279.


Childhood dermatomyositis is frequently complicated by deposition of calcium salts in the soft tissues. This calcinosis represents a major problem, as severe disability may result. Various drugs have been tried to dissolve the calcinosis, but the results of these trials are disappointing. In this article we present a case report of a 9-year-old girl treated with probenecid. This treatment led to a dramatic decrease in subcutaneous and intermuscular calcinosis. The authors call for controlled studies of probenecid treatment in calcinosis.

Publication types

  • Case Reports
  • Clinical Trial

MeSH terms

  • Calcinosis / drug therapy*
  • Calcinosis / etiology
  • Child
  • Clinical Trials as Topic
  • Dermatomyositis / complications*
  • Female
  • Humans
  • Probenecid / therapeutic use*


  • Probenecid