Clonazepam (Rivotril) and carbamazepine (Tegretol) in psychomotor epilepsy: a randomized multicenter trial

Epilepsia. 1981 Aug;22(4):415-20. doi: 10.1111/j.1528-1157.1981.tb06152.x.

Abstract

The antiepileptic properties of carbamazepine (Tegretol) and clonazepam (Rivotril) were compared in a double-blind randomized study comprising 36 patients with newly diagnosed, untreated psychomotor epilepsy (partial seizures with complex symptomatology). No significant differences were found between the two drugs during the 6 months of treatment. Measurements of concentrations in plasma confirmed that the patients exceeded the accepted lower limit for therapeutic range of the drugs.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Benzodiazepinones / therapeutic use*
  • Carbamazepine / administration & dosage
  • Carbamazepine / therapeutic use*
  • Child
  • Clinical Trials as Topic
  • Clonazepam / administration & dosage
  • Clonazepam / therapeutic use*
  • Double-Blind Method
  • Epilepsy, Temporal Lobe / drug therapy*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Random Allocation

Substances

  • Benzodiazepinones
  • Carbamazepine
  • Clonazepam