Renal transplantation in children less than 2 years of age

J Pediatr. 1981 Oct;99(4):535-9. doi: 10.1016/s0022-3476(81)80249-1.

Abstract

We report our experience with renal transplantation in ten infants receiving grafts at ages 1 to 21 months. All children were followed for at least six months posttransplantation, except two who died in the immediate postoperative period. Kidneys were obtained from cadaveric donors: four from anencephalic newborn infants and eight others from donors aged 9 months to 21 years at death. Immunosuppressive therapy consisted of prednisone, azathioprine, and antithymocyte globulin, with added doses of methylprednisolone for rejection. Patient survival at six months was 8/10, at two years 3/7 (three patients who were alive but were followed for less than two years are excluded), and at present 5/10. Graft survival at six months was 5/10, at two years 2/12, and at present 1/12. Cadaveric renal transplantation in small children is technically feasible, but the enormous time and effort involved in such an undertaking must be re-evaluated.

MeSH terms

  • Age Factors
  • Cadaver
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Graft Survival
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Infant
  • Kidney Transplantation*
  • Male
  • Tissue Donors

Substances

  • Immunosuppressive Agents