Lymphocytotoxic Antibody Responses to Transfusions in Potential Kidney Transplant Recipients

Transplantation. 1981 Sep;32(3):177-83. doi: 10.1097/00007890-198109000-00002.

Abstract

A series of 737 hemodialysis patients were studied for the relationship between lymphocytotoxic antibody formation and blood transfusions; 331 thereof were studied prospectively. With up to 20 transfusions, highly reactive (greater than 90% reactivity against random panel) antibodies were not found in any of the prospectively studied males or females without previous pregnancies. Nearly 90% of the males failed to form antibodies against greater than 10% of the panel donors. Patients with previous pregnancies developed antibodies at a much higher rate. Among 316 patients tested, antibodies against B cells were found more frequently than antibodies against T cells. Both T and B cell antibody levels often decreased in spite of additional transfusions. It is concluded that the risk of rendering a patient untransplantable because of sensitization as a result of transfusions is very small.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibody Formation
  • Antilymphocyte Serum* / immunology
  • B-Lymphocytes / immunology
  • Blood Transfusion*
  • Female
  • Humans
  • Immunization
  • Kidney Transplantation*
  • Male
  • Pregnancy
  • Prospective Studies
  • Risk
  • T-Lymphocytes / immunology
  • Transfusion Reaction

Substances

  • Antilymphocyte Serum