Pancreatic polypeptide. A review

Arch Surg. 1981 Oct;116(10):1256-64. doi: 10.1001/archsurg.1981.01380220010002.


Pancreatic polypeptide (PP), 36-amino acid peptide, may function as an important feedback inhibitor of pancreatic secretion after a meal. It arises from both islet and acinar cells of the pancreas. Release of PP by a meal, primarily protein, occurs in a biphasic manner. The first rapid release occurs as a result of vagal stimulation; the second, more prolonged rise (the so-called intestinal phase) occurs in response to hormonal stimulation, predominantly cholecystokinin. Plasma PP levels increase with age; PP levels are elevated above those of age-controlled normal subjects in diabetic patients and in some patients with pancreatic amine precursor uptake decarboxylase tumors. The value of plasma PP as a possible marker for pancreatic tumors is as yet unsettled but may be a valuable tool.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apudoma / analysis
  • Apudoma / blood*
  • Cattle
  • Chickens
  • Diabetes Mellitus / blood*
  • Dogs
  • Humans
  • Pancreas / metabolism
  • Pancreas / physiology
  • Pancreatic Neoplasms / analysis
  • Pancreatic Neoplasms / blood*
  • Pancreatic Polypeptide / analysis
  • Pancreatic Polypeptide / blood
  • Pancreatic Polypeptide / physiology*
  • Sheep
  • Swine


  • Pancreatic Polypeptide