Effects of combination treatment with vitamins E and C on chloasma and pigmented contact dermatitis. A double blind controlled clinical trial

Acta Vitaminol Enzymol. 1981;3(1):31-8.


A multi-clinical double-blind study on therapeutic effect of combination preparation of vitamins E and C was undertaken in comparison with single preparation of vitamin E and vitamin C in the treatment of chloasma or pigmented contact dermatitis (PCD). Combination treatment resulted in significantly better clinical improvement than vitamin C alone in both diseases. Objective data compiled from color difference measurements and color photographs revealed significantly better results with combination treatment in chloasma than vitamin C alone and, in PCD, than vitamin E or C alone. Differences in skin luminosity between hyperpigmented and normal areas significantly decreased in all three groups, with the combination group producing the most significant change. The total serum lipoperoxide level and its ratio to total serum lipids tended to decline in the combination group, and decreased significantly in vitamin E group. The sebum lipoperoxide level decreased significantly only in the combination group (EC).

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Ascorbic Acid / therapeutic use*
  • Clinical Trials as Topic
  • Dermatitis, Contact / drug therapy*
  • Double-Blind Method
  • Drug Therapy, Combination
  • Humans
  • Lipid Metabolism
  • Lipid Peroxides / metabolism
  • Melanosis / drug therapy*
  • Photography
  • Sebum / metabolism
  • Skin Pigmentation / drug effects
  • Tocopherols
  • Vitamin E / analogs & derivatives*
  • Vitamin E / therapeutic use
  • alpha-Tocopherol* / analogs & derivatives*


  • Lipid Peroxides
  • Vitamin E
  • alpha-Tocopherol
  • Ascorbic Acid
  • Tocopherols