The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep

Experientia. 1981;37(9):913-7. doi: 10.1007/BF01971753.


The effects of acute intravenous administration of synthetic DSIP, 25 nmoles/kg b.wt, on disturbed human sleep were tested in 6 middle-aged chronic insomniacs. The results were: longer sleep duration and a higher quality of sleep with fewer interruptions; slightly more REM-sleep, but no day-time sedation or other side effects though the sleep enhancing capacity was seen for up to 6 h of night sleep. Sleep-promoting effects occurred only in the second hour after injection, in the first hour a slight arousing effect was indicated. The study corroborates the findings of previous investigations in healthy subjects and shows that DSIP has a normalizing influence on human sleep regulation.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Clinical Trials as Topic
  • Delta Sleep-Inducing Peptide
  • Double-Blind Method
  • Female
  • Humans
  • Kinetics
  • Male
  • Middle Aged
  • Oligopeptides / therapeutic use*
  • Sleep Initiation and Maintenance Disorders / drug therapy*
  • Sleep Stages / drug effects
  • Sleep, REM / drug effects


  • Oligopeptides
  • Delta Sleep-Inducing Peptide