Reactivity of a monoclonal antibody with human ovarian carcinoma

J Clin Invest. 1981 Nov;68(5):1331-7. doi: 10.1172/jci110380.


A murine monoclonal antibody (OC125) has been developed that reacts with each of six epithelial ovarian carcinoma cell lines and with cryopreserved tumor tissue from 12 of 20 ovarian cancer patients. By contrast, the antibody does not bind to a variety of nonmalignant tissues, including adult and fetal ovary. OC125 reacts with only 1 of 14 cell lines derived from nonovarian neoplasms and has failed to react with cryostat sections from 12 nonovarian carcinomas.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal*
  • Antigens, Neoplasm / analysis*
  • Cell Line
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Lymphocytes / immunology
  • Mice
  • Neoplasms / immunology
  • Ovarian Neoplasms / immunology*


  • Antibodies, Monoclonal
  • Antigens, Neoplasm