Skeletal lesions in Hodgkin's disease can be due to different underlying causes. Reports on bone changes in Hodgkin's disease are reviewed and compared with two of our patients. The first patient, a fourteen year old girl with Hodgkin's disease, staged IV B, had skeletal involvement at the time of diagnosis. The other patient developed, three and a half years after the onset of the disease, bone lesions which might have been thought to be a manifestation of Hodgkin's disease. But by bacteriologic and histologic studies salmonella osteomyelitis could be proven.