Anatomy of the lamina cribrosa in human eyes

Arch Ophthalmol. 1981 Dec;99(12):2159-62. doi: 10.1001/archopht.1981.03930021035010.


Light microscopy of specimens of human eyes cut in cross section at the level of the lamina cribrosa showed variation in structural anatomy, as demonstrated previously in certain primate eyes. Connective tissue and glial cell structural elements were greater in nasal-temporal as compared with inferior and superior quadrants of the disc. This regional variation suggests a hypothesis for the specificity of early patterns of optic nerve dysfunction characteristic of glaucomatous optic neuropathy. In glaucomatous eyes, nerve head regions with relatively less structural tissue elements may yield early to detrimental effects of persistent pressure elevation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Connective Tissue Cells
  • Histological Techniques
  • Humans
  • Optic Disk / anatomy & histology*
  • Sclera / anatomy & histology*