Abstract
Fourteen patients with resistant cancers received high-dose chemotherapy and total body irradiation followed by rescue with autologous cryopreserved bone marrow cells. In seven patients, disease has remained in remission for periods up to two years. These data indicate that effectiveness of high-dose combined-modality therapy and bone marrow autotransplantation in patients with resistant cancer. The high incidence of non-marrow toxicity may be reduced by the use of this modality before patients have received extensive therapy.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Adult
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / adverse effects
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Bone Marrow Transplantation*
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Carcinoma / mortality
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Carcinoma / therapy*
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Cyclophosphamide / administration & dosage
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Drug Therapy, Combination
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Female
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Humans
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Lymphoma / mortality
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Lymphoma / therapy*
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Male
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Transplantation, Autologous
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Vinblastine / administration & dosage
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Whole-Body Irradiation* / adverse effects
Substances
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Antineoplastic Agents
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Vinblastine
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Cyclophosphamide