Clinical and histologic indications for extensive pancreatic resection in nesidioblastosis

Am J Surg. 1982 Jan;143(1):116-9. doi: 10.1016/0002-9610(82)90140-4.


Nine children with nesidioblastosis underwent pancreatic resection at St. Louis Children's Hospital. Four of these underwent 99 percent of near-total resection. Only one child required permanent insulin therapy postoperatively. Pathologic examination of the resected pancreases revealed a diffuse disturbance of the pancreatic architecture. Prolonged hypoglycemia can have devastating neurologic sequelae. Based on clinical experience and the pathologic demonstration of a diffuse process in the affected pancreas, it is advocated that near-total (99 percent) pancreatectomy is the primary procedure of choice for this disease.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Female
  • Humans
  • Hyperinsulinism / etiology
  • Infant
  • Infant, Newborn
  • Islets of Langerhans* / pathology
  • Male
  • Pancreatectomy / methods*
  • Pancreatic Diseases / complications
  • Pancreatic Diseases / pathology
  • Pancreatic Diseases / surgery*