In vivo changes in complement induced with peptidoglycan-polysaccharide polymers from streptococcal cell walls

Infect Immun. 1982 Jan;35(1):377-80. doi: 10.1128/IAI.35.1.377-380.1982.

Abstract

In rats injected with an arthropathogenic dose of streptococcal cell wall fragments, serum hemolytic activity decreased over the first 24 h and was then elevated from days 2 through 6 after injection. Hemolytic activity was again elevated at days 16 and 40. Levels of activity of alternative complement pathway, C3, and factor D were also altered.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Complement Activation*
  • Complement C3 / analysis
  • Complement Factor D / metabolism
  • Complement Pathway, Alternative*
  • Female
  • Peptidoglycan / pharmacology*
  • Polysaccharides, Bacterial / pharmacology*
  • Rats
  • Streptococcus pyogenes / analysis*
  • Time Factors

Substances

  • Complement C3
  • Peptidoglycan
  • Polysaccharides, Bacterial
  • Complement Factor D