Pathological changes in inbred strains of mice following early thymectomy and irradiation

Experientia. 1981 Dec 15;37(12):1341-3. doi: 10.1007/BF01948400.


Mice subjected to thymectomy and irradiation were found to develop a range of pathological change in various organs. These changes were accompanied by antibodies to a variety of self-components. The pattern of pathological and autoimmune change was found to vary with the strain. This strain-related expression did not appear to be associated with the major histocompatibility complex (H-2).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Fluorescent Antibody Technique
  • Humans
  • Infant, Newborn
  • Kidney / pathology
  • Liver / pathology
  • Mice
  • Mice, Inbred Strains / physiology*
  • Radiation Effects*
  • Species Specificity
  • Thymectomy*
  • Thyroid Gland / pathology