Oxalate metabolism and renal calculi

J Urol. 1982 Jan;127(1):148-51. doi: 10.1016/s0022-5347(17)53649-6.


Changes in oxalate excretion (together with changes in urinary volume) constitute the most important factors in altering the probability of renal stone formation. However, investigations on oxalate metabolism have been sparse, perhaps because of the lack of an accurate method for measuring oxalate in biologic fluids. Available data clearly implicate increased urinary oxalate excretion as the etiological factor in stone formation in two groups of patients--those with primary hyperoxaluria and those with gastrointestinal malabsorption. Evidence for the existence of hyperoxaluria in the patient with the "garden" variety of calcium oxalate stones is less persuasive.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Calcium Oxalate / adverse effects
  • Diet
  • Gastrointestinal Diseases / metabolism
  • Glyoxylates / metabolism
  • Humans
  • Intestinal Absorption
  • Kidney Calculi / chemically induced
  • Kidney Calculi / metabolism*
  • Oxalates / biosynthesis
  • Oxalates / metabolism*
  • Oxalates / urine
  • Oxalic Acid
  • Rats
  • Rats, Inbred Strains
  • Urinary Calculi / metabolism


  • Glyoxylates
  • Oxalates
  • Calcium Oxalate
  • Oxalic Acid
  • glyoxylic acid