Maintenance immunotherapy with BCG in non-Hodgkin's malignant lymphomas: a progress report of randomized trial

Recent Results Cancer Res. 1982;80:92-7. doi: 10.1007/978-3-642-81685-7_15.


Ninety-eight patients with non-Hodgkin's malignant lymphoma were first put into complete remission by a combination of chemotherapy and radiotherapy, and then received one course of chemotherapy as reinforcement. They were then randomized to receive either maintenance BCG therapy or no other treatment. Ninety-three patients were available for this analysis. There was a significant difference (P = 0.021) in relapse-free survival times between the two groups of patients. This difference is particularly significant in male patients, in patients ages 50-65 years, in all histologic classes, in patients treated after an initial relapse, and in clinical stages I and II. There was also a difference in crude survival, but the difference was not significant.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Clinical Trials as Topic
  • Female
  • Follow-Up Studies
  • Humans
  • Immunotherapy*
  • Lymphoma / therapy*
  • Male
  • Middle Aged
  • Mycobacterium bovis / immunology*