Spironolactone therapy in infants with congestive heart failure secondary to congenital heart disease

Arch Dis Child. 1981 Dec;56(12):934-8. doi: 10.1136/adc.56.12.934.


The efficacy of treatment with spironolactone for congestive heart failure secondary to congenital heart disease was studied in 21 infants under 1 year of age. All received digoxin and chlorothiazide. In addition, group A (n = 10) was given supplements of potassium and group B (n = 11) received spironolactone. Daily clinical observations of vital signs, weight, hepatomegaly, and vomiting were recorded. Paired t test analysis showed significant reduction in liver size and weight (P less than 0.01) and respiratory rate (P less than 0.05) in group B, and less significant decreases in group A. The incidence of vomiting was slightly lower in group B. We conclude that the addition of spironolactone hastens and enhances the response to standard treatment with digoxin and chlorothiazide in infants with congestive heart failure.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Chlorothiazide / therapeutic use
  • Clinical Trials as Topic
  • Digoxin / therapeutic use
  • Drug Therapy, Combination
  • Female
  • Heart Defects, Congenital / complications*
  • Heart Failure / drug therapy*
  • Heart Failure / etiology
  • Humans
  • Infant
  • Male
  • Potassium / therapeutic use
  • Random Allocation
  • Spironolactone / therapeutic use*


  • Spironolactone
  • Digoxin
  • Chlorothiazide
  • Potassium