Screening for cystic fibrosis by died blood spot trypsin assay

Arch Dis Child. 1982 Jan;57(1):18-21.


Immunoreactive trypsin was measured in dried blood specimens from 14,000 infants. A second test was performed in 0 . 2% of the population in whom blood trypsin levels were greater than 80 ng/ml. Five infants with cystic fibrosis were then detected, with only one case of persistent hypertrypsinaemia in whom this diagnosis could not be established. No false-negative test results have yet been identified. Seventeen infants with cystic fibrosis were tested inthe first 2 weeks of life, only one of whom had a blood trypsin concentration less than 80 ng/ml.

MeSH terms

  • Cystic Fibrosis / diagnosis*
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Infant, Newborn
  • Male
  • Mass Screening / methods*
  • Trypsin / blood*


  • Trypsin