Soya protein antibodies in man: their occurrence and possible relevance in coeliac disease

J Clin Pathol. 1982 Mar;35(3):319-22. doi: 10.1136/jcp.35.3.319.


Circulating antibodies to soya-derived protein antigens have been measured in patients with duodenitis, Crohn's disease, ulcerative colitis and coeliac disease. Significantly raised antibody titres were found frequently in the coeliac group, particularly those patients showing a suboptimal response to a gluten-free diet, but rarely in subjects with other gastrointestinal diseases. Antisoya activity was not necessarily accompanied by antibodies to other common dietary antigens. We suggest that some coeliacs may have an associated dietary soya sensitivity which could adversely influence their response to gluten withdrawal.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies / analysis*
  • Celiac Disease / diet therapy
  • Celiac Disease / immunology*
  • Dietary Proteins
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fluorescent Antibody Technique
  • Gastrointestinal Diseases / immunology*
  • Hemagglutination
  • Humans
  • Immunoglobulin G / analysis
  • Male
  • Middle Aged
  • Plant Proteins / immunology*
  • Reference Values
  • Soybeans*


  • Antibodies
  • Dietary Proteins
  • Immunoglobulin G
  • Plant Proteins