Reduced natural killer cell activity in non-hodgkin's lymphoma

Boll Ist Sieroter Milan. 1981 Nov;60(5):394-407.


Natural Killer (NK) activity is investigated in 20 patients with non-Hodgkin's Lymphoma (NHL) and in 20 healthy subjects. Peripheral blood lymphocytes are used as effector cells, and 51Cr labelled K562 myeloid cells as targets. Experiments are carried out either at effector/target ratio of 20:1 or 40:1, in 4 hrs Cr released assay. As compared to controls, a reduced NK activity is found in NHL patients, but that difference is statistically significant only for the patients in active disease. Thus, patients in clinical remission display a better preservation of NK function. It is suggested that the study of NK function might offer a helpful tool in following the clinical course and the efficacy of therapy in NHL.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • B-Lymphocytes / immunology
  • Humans
  • Killer Cells, Natural / immunology*
  • Leukocyte Count
  • Lymphoma / immunology*
  • Middle Aged
  • T-Lymphocytes / immunology