Cimetidine in the management of symptomatic patients with duodenitis: a double-blind controlled trial

Dig Dis Sci. 1982 Mar;27(3):217-9. doi: 10.1007/BF01296918.


Twenty-one adult outpatients with dyspepsia and endoscopically proven duodenitis without chronic ulceration completed a double-blind trial of either cimetidine (1 g/day) or placebo. Treatment with cimetidine for 6 weeks resulted in a significant improvement in symptoms and in the endoscopic appearance of the duodenitis when compared to treatment with placebo. The symptomatic and endoscopic improvement, however, was not associated with any significant change in the histological grading of the duodenitis.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Cimetidine / therapeutic use*
  • Clinical Trials as Topic
  • Double-Blind Method
  • Duodenitis / drug therapy*
  • Duodenoscopy
  • Duodenum / anatomy & histology
  • Guanidines / therapeutic use*
  • Humans
  • Middle Aged
  • Placebos


  • Guanidines
  • Placebos
  • Cimetidine