Clinical comparison of Tc-99m N,N'-bis(mercaptoacetamido)ethylenediamine and [131I]ortho-iodohippurate for evaluation of renal tubular function: concise communication

J Nucl Med. 1982 May;23(5):377-80.

Abstract

Recent experiments in normal animals have shown that Tc-99m N,N'-bis(mercaptoacetamido)ethylenediamine (Tc-99m DADS) is a potential technetium-99m-labeled replacement for [131I]ortho-iodohippurate(I-131 Hipp). We compared the two agents in eleven patients with renal transplants (serum creatinine range: 0.9--5.7 mg/dl). Digital and analog images were recorded for 30 min and after voiding. The results indicate that the relative extraction efficiency index of Tc-99m DADS is 76% +/- 3 (mean +/- s.e.m.), that the leading-edge parenchymal transit time of Tc-99m DADS is 137% +/- 6, and that the percentage of injected Tc-99m DADS in the bladder at 30 min is 25% +/- 4 of that of I-131 Hipp (all p less than 0.05). Forty percent of patients showed some hepatobiliary excretion of Tc-99m DADS. We conclude that the biologic properties of Tc-99m DADS are inferior to those of I-131 Hipp and that analogs of Tc-99m DADS should be evaluated in an attempt to find a more suitable technetium-99m-labeled replacement for I-131 Hipp.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Ethylenediamines*
  • Humans
  • Iodine Radioisotopes*
  • Iodohippuric Acid*
  • Kidney Transplantation
  • Kidney Tubules / diagnostic imaging*
  • Organotechnetium Compounds*
  • Pentetic Acid
  • Radionuclide Imaging
  • Technetium Tc 99m Pentetate
  • Technetium*

Substances

  • Ethylenediamines
  • Iodine Radioisotopes
  • Organotechnetium Compounds
  • Iodohippuric Acid
  • Technetium
  • technetium Tc 99m N,N'-bis(mercaptoacetamido)ethylenediamine
  • Pentetic Acid
  • Technetium Tc 99m Pentetate