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. 1982 Jul 22;298(5872):347-50.
doi: 10.1038/298347a0.

Synthesis and Assembly of Hepatitis B Virus Surface Antigen Particles in Yeast

Synthesis and Assembly of Hepatitis B Virus Surface Antigen Particles in Yeast

P Valenzuela et al. Nature. .

Abstract

The surface antigens of hepatitis B virus (HBsAg) has been synthesized in the yeast Saccharomyces cerevisiae by using an expression vector that employs the 5'-flanking region of yeast alcohol dehydrogenase I as a promotor to transcribe surface antigen coding sequences. The protein synthesized in yeast is assembled into particles having properties similar to the 22-nm particles secreted by human cells.

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