Muscle acid protease activity in amyotrophic lateral sclerosis: correlation with clinical and pathologic features

Neurology. 1982 Aug;32(8):901-3. doi: 10.1212/wnl.32.8.901.


Acid protease activity was increased in skeletal muscle of patients with ALS. The highest levels of activity were found in individuals with the clinically and histologically most affected muscle. High levels of proteolytic activity correlated with the extent of muscle atrophy, the presence of target fibers and the overall severity of disease.

MeSH terms

  • Adult
  • Amyotrophic Lateral Sclerosis / enzymology*
  • Amyotrophic Lateral Sclerosis / pathology
  • Aspartic Acid Endopeptidases
  • Endopeptidases / metabolism*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscles / enzymology*
  • Muscles / pathology


  • Endopeptidases
  • Aspartic Acid Endopeptidases