Synthesis and metabolism of prostaglandins E2, F2alpha and D2 by the rat gastrointestinal tract. Stimulation by a hypertonic environment in vitro

H R Knapp; O Oelz; B J Sweetman; J A Oates

doi:10.1016/0090-6980(78)90141-7

Synthesis and metabolism of prostaglandins E2, F2alpha and D2 by the rat gastrointestinal tract. Stimulation by a hypertonic environment in vitro

Prostaglandins. 1978 May;15(5):751-7. doi: 10.1016/0090-6980(78)90141-7.

Authors

H R Knapp, O Oelz, B J Sweetman, J A Oates

PMID: 704901
DOI: 10.1016/0090-6980(78)90141-7

Abstract

Whole cell preparations of rat stomach corpus, jejunum, and colon were incubated and the released prostaglandin E2 (PGE2), PGF2alpha, PGD2, 15 keto-13,14 dihydro PGE2, and 15 keto-13, 14 dihydro PGF2alpha were measured by combined gas chromatography-mass spectrometry. All regions made PGD2 and possessed a high capacity for production 15 keto-13,14 dihydro derivatives of both PGE2 and PGF2alpha. Hypertonic sucrose solutions resulted in concentration-dependent increases in prostaglandin release, particularly of PGE2 and its metabolite. It is suggested that PG's may play a role in the local effects of luminal hyperosomolarity on digestive tract functions.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Digestive System / drug effects
Digestive System / metabolism*
Hypertonic Solutions / pharmacology*
In Vitro Techniques
Male
Prostaglandins / metabolism*
Prostaglandins D / biosynthesis
Prostaglandins D / metabolism*
Prostaglandins E / biosynthesis
Prostaglandins E / metabolism*
Prostaglandins F / biosynthesis
Prostaglandins F / metabolism*
Rats
Sucrose / pharmacology
Time Factors

Substances

Hypertonic Solutions
Prostaglandins
Prostaglandins D
Prostaglandins E
Prostaglandins F
Sucrose