The nucleotide sequence of the HIS4 region of yeast

Gene. 1982 Apr;18(1):47-59. doi: 10.1016/0378-1119(82)90055-5.


We have determined the nucleotide sequence of the yeast HIS4 gene and its 5' and 3' flanking sequences. The protein chain has a calculated Mr-value of 87 935. Th 5' end of the HIS4 transcript maps at a position 63 bp upstream from the site of initiation of protein synthesis. The 3' end of the HIS4 transcript maps at a position approx. 118 bp after the UAG termination codon. There is no evidence for intervening sequences within the transcription unit. Functional sub-regions within the HIS4 coding frame have been identified by determining the sequence changes for various his4 mutations.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Codon
  • DNA, Fungal / genetics*
  • Gene Expression Regulation
  • Genes
  • Genes, Regulator
  • Histidine / genetics*
  • RNA, Messenger / genetics
  • Saccharomyces cerevisiae / genetics*
  • Transcription, Genetic


  • Codon
  • DNA, Fungal
  • RNA, Messenger
  • Histidine

Associated data

  • GENBANK/J01331