Stimulatory effects of tolbutamide infusion on plasma glucagon in insulin-dependent diabetic subjects

J Clin Endocrinol Metab. 1982 Feb;54(2):459-62. doi: 10.1210/jcem-54-2-459.


The effect of iv tolbutamide on endogenous glucagon levels was measured in nine insulin-dependent diabetic patients chosen because they evidenced no C-peptide response to beta-cell secretagogues. Basal glucagon levels were not suppressed by a sustained tolbutamide infusion; in fact, a slight stimulatory effect was observed at 5, 10, 30, and 45 min. In the absence of detectable insulin secretory capacity and suboptimal insulin replacement, tolbutamide appears to be a stimulus, not a suppressant, of glucagon secretion.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Blood Glucose / metabolism
  • C-Peptide / blood
  • Diabetes Mellitus / blood*
  • Female
  • Glucagon / blood*
  • Humans
  • Kinetics
  • Male
  • Middle Aged
  • Tolbutamide / pharmacology*


  • Blood Glucose
  • C-Peptide
  • Glucagon
  • Tolbutamide