Transport of Na+ by monensin across bimolecular lipid membranes

Biochim Biophys Acta. 1982 Jan 4;684(1):127-32. doi: 10.1016/0005-2736(82)90056-6.

Abstract

Transmembrane 22Na fluxes across bimolecular lipid membranes are measured under two different experimental conditions: (a) the pH is the same in the two bulk aqueous solutions on either side of the membrane while the concentrations of Na+ are different; (b) the concentration of Na+ are identical but pH of the two solutions are different. In this latter case, the transport of Na+ occurs in the opposite direction to the difference of the proton concentration. In both cases, the electrical charge flux in negligible. A transport model is proposed to account for the experimental data.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Transport, Active
  • Furans*
  • Hydrogen-Ion Concentration
  • Kinetics
  • Lipid Bilayers*
  • Models, Biological
  • Models, Molecular
  • Monensin*
  • Sodium*

Substances

  • Furans
  • Lipid Bilayers
  • Monensin
  • Sodium