Chlorpropamide-induced optic neuropathy

Arch Intern Med. 1982 Feb;142(2):381.


A 65-year-old woman with adult-onset diabetes treated with chlorpropamide (Diabenese) had a toxic optic neuropathy that resolved with discontinuation of chlorpropamide therapy. Visual loss occurs in diabetics for a variety of reasons, and accurate diagnosis is necessary to institute appropriate therapy. The possibility of a drug-induced optic neuropathy should be considered in the differential diagnosis of visual loss in diabetics.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Chlorpropamide / adverse effects*
  • Color Perception / drug effects
  • Female
  • Humans
  • Vision Disorders / chemically induced*
  • Visual Acuity / drug effects


  • Chlorpropamide