Complications of gastroesophageal reflux in patients with cystic fibrosis

J Pediatr. 1982 Apr;100(4):536-40. doi: 10.1016/s0022-3476(82)80748-8.


Seven patients with cystic fibrosis who had complications of gastroesophageal reflux including abdominal pain, peptic esophagitis, upper gastrointestinal hemorrhage, and esophageal stricture are described. We believe that these are gastrointestinal complications of CF and that they may be responsible for significant morbidity. The mechanical influence of a depressed diaphragm caused by hyperinflation, along with increased abdominal pressure with chronic coughing, may contribute to GER in CF. Early detection and treatment are important not only to prevent esophageal complications but also to increase the quality of life by relief of pain and by avoiding the resultant decrease in appetite, which can contribute to malnutrition.

MeSH terms

  • Adolescent
  • Adult
  • Antacids / therapeutic use
  • Child
  • Cimetidine / therapeutic use
  • Cystic Fibrosis / complications*
  • Esophageal Stenosis / etiology
  • Esophageal Stenosis / therapy
  • Esophagitis, Peptic / etiology
  • Female
  • Gastroesophageal Reflux / diagnosis
  • Gastroesophageal Reflux / etiology*
  • Gastroesophageal Reflux / therapy
  • Humans
  • Hydrogen-Ion Concentration
  • Male
  • Posture


  • Antacids
  • Cimetidine