An epidemic of Kawasaki syndrome in Hawaii

J Pediatr. 1982 Apr;100(4):552-7. doi: 10.1016/s0022-3476(82)80751-8.


A community-wide outbreaks of Kawasaki syndrome, apparently the first in the United States, occurred in Hawaii in the first half of 1978. Twenty-seven of the 33 cases were subjected to intensive epidemiologic and microbiologic study. Patients with Kawasaki syndrome, compared to the general population, more often had Japanese ancestry, high-income status, and possibly a history of respiratory infection in the preceding month (44%). Staphylococcus aureus was not found in high frequency in the patients (15%), and viral cultures and serologic studies, immune electron microscopy, and guinea pig and primate inoculation did not reveal a causative microorganism. Febrile illnesses in guinea pigs inoculated with a skin biopsy specimen should not be further passaged.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Child
  • Child, Preschool
  • Disease Outbreaks / epidemiology*
  • Disease Outbreaks / etiology
  • Disease Outbreaks / microbiology
  • Female
  • Hawaii
  • Humans
  • Income
  • Infant
  • Japan / ethnology
  • Lymphatic Diseases / epidemiology*
  • Male
  • Mucocutaneous Lymph Node Syndrome / epidemiology*
  • Mucocutaneous Lymph Node Syndrome / etiology
  • Mucocutaneous Lymph Node Syndrome / microbiology
  • Respiratory Tract Infections / complications