Influence of fasting on intestinal permeability and disease activity in patients with rheumatoid arthritis

Scand J Rheumatol. 1982;11(1):33-8. doi: 10.3109/03009748209098111.


We have investigated the influence of fasting and lactovegetarian diet on intestinal and non-intestinal permeability in 5 patients with rheumatoid arthritis. We used low-molecular weight polyethyleneglycols (PEG 400) as probe molecules and a deterministic mathematical model to assess the permeability characteristics. Both intestinal and non-intestinal permeability decreased after fasting, but increased again during a subsequent lactovegetarian diet regime. Concomitantly it appeared that disease activity, as shown by a clinical six-joint score, first decreased and then increased again. The results indicate that, unlike lactovegetarian diet, fasting may ameliorate the disease activity and reduce both the intestinal and the non-intestinal permeability in rheumatoid arthritis.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arthritis, Rheumatoid / physiopathology*
  • Fasting*
  • Humans
  • Intestinal Absorption / drug effects
  • Intestines / physiopathology*
  • Permeability
  • Polyethylene Glycols / pharmacology
  • Time Factors


  • Polyethylene Glycols