Queuine, a modified base incorporated posttranscriptionally into eukaryotic transfer RNA: wide distribution in nature

Science. 1982 Apr 2;216(4541):55-6. doi: 10.1126/science.7063869.


Queuine, a modified base found in transfer RNA, appears to be a new dietary factor because (i) previous studies have shown that mice require it for the expression of queuine-containing transfer RNA's but apparently do not synthesize it, and (ii) significant amounts of free queuine are present in common plant and animal food products.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Diet
  • Eukaryotic Cells / metabolism
  • Germ-Free Life
  • Guanine / analogs & derivatives*
  • Guanine / metabolism
  • RNA, Transfer / metabolism*


  • Guanine
  • queuine
  • RNA, Transfer