Impaired clot retraction in thrombocytopenia due to methyldopa

South Med J. 1982 Mar;75(3):374-5. doi: 10.1097/00007611-198203000-00036.


We have described a case of thrombocytopenic purpura caused by methyldopa. A methyldopa-dependent antiplatelet antibody as the mechanism of the patient's thrombopenia was suggested by a positive clot retraction inhibition test. This simple in vitro test should be done more often in suspected cases of drug-induced thrombocytopenia.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Clot Retraction*
  • Female
  • Humans
  • Methyldopa / adverse effects*
  • Middle Aged
  • Thrombocytopenia / chemically induced*
  • Thrombocytopenia / diagnosis


  • Methyldopa