EEG monitoring of focal lesions of the blood-brain barrier

Acta Neurol Scand. 1982 Jan;65(1):51-8. doi: 10.1111/j.1600-0404.1982.tb03061.x.

Abstract

This paper presents a modified method for the EEG detection and monitoring of small focal blood-brain barrier (BBB) lesions. The method uses high dose IV penicillin (1.2 X 10(6) mu/kg) to produce a spike focus at BBB lesions, penicillin encephalopathy. The EEG is recorded and the epileptic spikes are counted by an automatic computer program. The computer produces an objective quantitative results. The method is verified empirically on traumatic and radiation BBB lesions.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Blood-Brain Barrier* / drug effects
  • Blood-Brain Barrier* / radiation effects
  • Cats
  • Cerebral Cortex / injuries*
  • Cerebral Cortex / radiation effects
  • Electroencephalography / methods*
  • Evoked Potentials / drug effects
  • Evoked Potentials / radiation effects
  • Female
  • Penicillin G
  • Radiation Injuries, Experimental / diagnosis
  • Seizures / chemically induced

Substances

  • Penicillin G