A prospective study of 18 patients with cholestasis of pregnancy

Am J Obstet Gynecol. 1982 Mar 15;142(6 Pt 1):621-5. doi: 10.1016/s0002-9378(16)32430-9.


In this prospective study we evaluate the role of serum bile acids in the investigation and management of cholestasis of pregnancy in a detailed study of 18 patients. Bile acids were the most sensitive diagnostic test. The increased incidence of fetal distress (33.3% in this series) and meconium-stained fluid (58.3%) did not correlate with very high values of bile acids in maternal serum, umbilical cord serum, or amniotic fluid. Treatment of pruritus with cholestyramine and/or phenobarbital is ineffective in this condition, induction of labor is suggested once fetal lung maturity is established.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Amniotic Fluid / analysis
  • Bile Acids and Salts / analysis
  • Bile Acids and Salts / blood
  • Cholestasis / therapy*
  • Cholestyramine Resin / therapeutic use
  • Drug Therapy, Combination
  • Evaluation Studies as Topic
  • Female
  • Fetal Blood / analysis
  • Fetal Distress / drug therapy
  • Fetal Organ Maturity
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Labor, Induced
  • Lung / embryology
  • Meconium / analysis
  • Phenobarbital / therapeutic use
  • Pregnancy
  • Pregnancy Complications / therapy*
  • Prospective Studies


  • Bile Acids and Salts
  • Cholestyramine Resin
  • Phenobarbital