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. 1982 Mar;75(3):451-4.
doi: 10.1111/j.1476-5381.1982.tb09161.x.

Effects of Caffeine, Theophylline and Theobromine on Scheduled Controlled Responding in Rats

Free PMC article

Effects of Caffeine, Theophylline and Theobromine on Scheduled Controlled Responding in Rats

J M Carney. Br J Pharmacol. .
Free PMC article

Abstract

1 Rats were trained to respond under a variable interval 30 s (VI 30) schedule of food reinforcement. Caffeine (0.32-32 mg/kg), theophylline (1.0-56 mg/kg) and theobromine (10-320 mg/kg) in general produced dose-related decreases in operant responding. At relatively low doses, caffeine (1.0 mg/kg) and theophylline (3.2 mg/kg) produced slight but nonsignificant increases in VI 30 responding. 3 The rank order of potency for producing decreases in responding was caffeine greater than theophylline greater than theobromine. 4 Daily caffeine injections (32 mg/kg, i.p.) resulted in the development of caffeine tolerance. This tolerance was characterized by a 6 fold shift to the right in the caffeine dose-effect curve. Saline substitution for the 32.0 mg/kg caffeine maintenance dose resulted in a substantial decrease in responding.

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References

    1. Biochemistry. 1967 Apr;6(4):1079-87 - PubMed
    1. Psychopharmacologia. 1966;9(2):170-82 - PubMed
    1. J Pharmacol Exp Ther. 1968 Sep;163(1):172-87 - PubMed
    1. Eur J Pharmacol. 1970 Apr;10(1):64-71 - PubMed
    1. J Neurochem. 1971 Aug;18(8):1419-31 - PubMed

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