Single dose treatment of trichomoniasis

J Int Med Res. 1982;10(2):129-30. doi: 10.1177/030006058201000212.


Oral treatment for trichomonas vaginalis infection is now well established. In a previous paper, we established the value of a high single dose regimen of metronidazole for this condition by demonstrating its efficacy in a double-blind controlled study. Tinidazole is another accepted trichomonacide. By means of a single-blind controlled trial, we demonstrate that a 2 g single dose of tinidazole is as effective as a 2 g single dose metronidazole in the treatment of vaginal trichomoniasis. The cure rate for tinidazole was 95% and for metronidazole it was 97.5%. No side-effects were reported with either regimen.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Female
  • Humans
  • Metronidazole / administration & dosage*
  • Metronidazole / therapeutic use
  • Nitroimidazoles / administration & dosage*
  • Tinidazole / administration & dosage*
  • Tinidazole / therapeutic use
  • Trichomonas Vaginitis / drug therapy*


  • Nitroimidazoles
  • Tinidazole
  • Metronidazole