Pharmacokinetics and efficacy of chlorpheniramine in children

J Allergy Clin Immunol. 1982 Apr;69(4):376-81. doi: 10.1016/0091-6749(82)90149-x.


Chlorpheniramine is widely used, but there is very little information about its pharmacokinetics and efficacy in children. In 11 patients with allergic rhinitis, ages 6 to 16 yr, we found a mean serum chlorpheniramine half-life of 13.1 +/- 6.3 hr, a mean volume of distribution of 7.0 +/- 2.8 L/kg, and a mean clearance rate of 7.2 +/- 3.2 ml/min/kg. Suppression of symptoms and signs of allergic rhinitis and suppression of the histamine-induced wheal and flare responses occurred when mean serum chlorpheniramine concentration ranged from 2.3 to 12.1 and 4.1 to 10.0 ng/ml, respectively. This combined with the large volume of distribution for the drug, suggest that tissue binding is an important aspect of chlorpheniramine pharmacokinetics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Chlorpheniramine / adverse effects
  • Chlorpheniramine / metabolism*
  • Chlorpheniramine / therapeutic use
  • Female
  • Humans
  • Kinetics
  • Male
  • Rhinitis, Allergic, Seasonal / drug therapy*


  • Chlorpheniramine