The effects of systemic Podophyllin toxicity on the bone marrow are a manifestation of this agent's potent antimitotic activity. Our patient experienced a transient aregenerative anemia with leukopenia and thrombocytopenia. The bone marrow was hypocellular with cytoplasmic vacuolation of myeloid precursors and increased numbers of mitotic figures. Megakaryocytes were normal in number and morphology. Hematologic resolution followed discontinuance of topical therapy.