The dilution of proprietary corticosteroid ointments--an attempt to evaluate relative clinical potencies

Br J Dermatol. 1982 Apr;106(4):445-7. doi: 10.1111/j.1365-2133.1982.tb04538.x.

Abstract

Ten subjects were assessed using the vasoconstrictor assay technique in a double-blind study in order to evaluate the potencies of several diluted and undiluted proprietary corticosteroid ointments. Results showed that clobetasol propionate 0.05% (Dermovate) ointment at a dilution of one part in ten (clobetasol propionate 0.005%) in white soft paraffin was equipotent with betamethasone valerate 0.1% (Betnovate) ointment; and no difference in potency was demonstrated between beclomethasone dipropionate 0.025% (Propaderm), betamethasone valerate 0.1% (Betnovate) and clobetasone butyrate 0.05% (Eumovate).

Publication types

  • Comparative Study

MeSH terms

  • Administration, Topical
  • Anti-Inflammatory Agents / pharmacology
  • Double-Blind Method
  • Female
  • Glucocorticoids / administration & dosage
  • Glucocorticoids / pharmacology*
  • Humans
  • Hydrocortisone
  • Male
  • Ointment Bases
  • Skin / blood supply*
  • Skin / drug effects
  • Vasoconstriction / drug effects*

Substances

  • Anti-Inflammatory Agents
  • Glucocorticoids
  • Ointment Bases
  • Hydrocortisone