Intracranial myospherulosis

Hum Pathol. 1982 Jun;13(6):596-7. doi: 10.1016/s0046-8177(82)80279-7.


A 54-year-old man developed a post-traumatic brain abscess, and antibiotic ointment was instilled into the abscess cavity. The involved tissue was subsequently excised and was shown to contain the characteristic saccules and spherules of myospherulosis. The history of ointment usage further strengthens the association of petrolatum with the development of these structures. This is the first reported case of intracranial myospherulosis.

Publication types

  • Case Reports

MeSH terms

  • Brain Diseases / chemically induced
  • Brain Diseases / diagnosis
  • Brain Diseases / pathology*
  • Erythrocytes, Abnormal*
  • Humans
  • Male
  • Middle Aged
  • Ointment Bases / adverse effects*
  • Petrolatum / adverse effects*
  • Pharmaceutic Aids / adverse effects*
  • Spherocytes*


  • Ointment Bases
  • Pharmaceutic Aids
  • Petrolatum