The lipid composition of human liver microsomes

Lipids. 1982 Apr;17(4):317-20. doi: 10.1007/BF02534948.


The lipid composition of human liver microsomes isolated from liver biopsy samples obtained at abdominal surgery has been determined. Human liver microsomal phospholipid is composed of 49% phosphatidylcholine, 31% phosphatidylethanolamine, 14% phosphatidylserine + phosphatidylinositol and 6% sphingomyelin, very similar to the phospholipid composition of rat liver microsomes. The fatty acid composition of human liver microsomes is remarkable only for its content of polyunsaturated fatty acids, with 20% of the fatty acids consisting of arachidonic, docosatetraenoic, docosapentaenoic and docosahexaenoic acids. This value contrasts with 33% in rats and 9% in rabbits. The molar cholesterol/phospholipid ratio in human liver microsomes is 0.069, similar to the ratio in rat and rabbit microsomes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biopsy
  • Cholesterol / analysis
  • Cholesterol / blood
  • Fatty Acids / analysis
  • Humans
  • Male
  • Microsomes, Liver / analysis*
  • Middle Aged
  • Phospholipids / analysis*


  • Fatty Acids
  • Phospholipids
  • Cholesterol