Effects of interruption of the enterohepatic circulation of bile acids on the transport of very low density-lipoprotein triglycerides

Metabolism. 1982 May;31(5):438-44. doi: 10.1016/0026-0495(82)90231-1.


An increase in plasma very low density lipoprotein-triglycerides (VLDL-TG) is seen frequently during treatment with bile acid-binding resins. The purpose of this study was to determine whether this increment in VLDL-TG is due mainly to an increase in synthesis of VLDL, or to an enhanced catabolism. Three types of patients were studied: (1) 7 normotriglyceridemic subjects. (2) 4 obese patients, and (3) 9 hypertriglyceridemic patients. Before treatment they underwent a study of VLDL-TG kinetics that employed multicompartmental analysis of specific activity curves following injection of 3H-glycerol. The patients were then treated with a bile acid-binding resin, either cholestyramine or colestipol, for several weeks to several months. At the end of the treatment period, they were readmitted to the hospital for a second study of VLDL-TG kinetics. The patients showed a variable response to resin therapy. Many had an increase in concentrations of VLDL-TG, but others had no change or even a slight decrease. However, analysis of the data showed a high correlation between change in production rates of VLDL-TG and change in concentration. Also, when the data for the 20 patients were combined, there was a statistically significant increase in both synthetic rates and concentrations of VLDL-TG; in contrast, the fractional catabolic rate (FCR) was unchanged by therapy. Therefore, our data show that when treatment with bile acid sequestrants causes an increase in plasma VLDL-TG, the increase is due to an increment in production and not to a decrease in catabolism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Bile Acids and Salts / blood*
  • Enterohepatic Circulation*
  • Humans
  • Hypercholesterolemia / blood
  • Hyperlipoproteinemia Type IV / blood
  • Lipoproteins, VLDL / blood*
  • Male
  • Middle Aged
  • Obesity / blood
  • Triglycerides / blood*


  • Bile Acids and Salts
  • Lipoproteins, VLDL
  • Triglycerides
  • very low density lipoprotein triglyceride