Interactions between inosine and adenosine: experimental researches

Res Commun Chem Pathol Pharmacol. 1982 Mar;35(3):397-404.

Abstract

Experimental investigations have shown that inosine enhances purinergic reactivity. This was examined with adenosine at the level of the cardiovascular, intestinal and uterine musculature. The mechanism of this activity may probably be inhibition of uptake without significantly altering serum adenosinase.

MeSH terms

  • Adenosine / metabolism
  • Adenosine / pharmacology*
  • Animals
  • Drug Interactions
  • Duodenum / drug effects
  • Duodenum / metabolism
  • Female
  • Heart / drug effects
  • In Vitro Techniques
  • Inosine / metabolism
  • Inosine / pharmacology*
  • Male
  • Mice
  • Myocardium / metabolism
  • N-Glycosyl Hydrolases / blood
  • Ranidae
  • Rats
  • Uterus / drug effects
  • Uterus / metabolism

Substances

  • Inosine
  • N-Glycosyl Hydrolases
  • adenosine nucleosidase
  • Adenosine