Growth hormone stimulates longitudinal bone growth directly

Science. 1982 Jun 11;216(4551):1237-9. doi: 10.1126/science.7079756.


Local administration of human growth hormone in vivo to the cartilage growth plate of the proximal tibia of hypophysectomized rats resulted in accelerated longitudinal bone growth. This finding suggests that growth hormone directly stimulates the cells in the growth plate, and does not support the theory that the increase in the plasma concentration of somatomedin that follows growth hormone administration is the cause of this stimulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Development / drug effects*
  • Bone and Bones / drug effects*
  • Growth Hormone / pharmacology*
  • Male
  • Prolactin / pharmacology
  • Rats
  • Somatomedins / pharmacology
  • Stimulation, Chemical


  • Somatomedins
  • Prolactin
  • Growth Hormone