Evidence for a Major Dominance Component in the Variation of Serum Pepsinogen I Levels

Am J Hum Genet. 1982 May;34(3):395-401.


We report here a variance component analysis of the distribution of serum pepsinogen I levels in normal individuals, using a maximum-likelihood method on entire pedigrees. The results indicate a broad heritability of 91%, with some 74% being attributed to a dominance component. This is consistent with the hypothesis that the pepsinogen I level in normals is principally determined by the action of major genes, as also seems to be the case for duodenal ulcer patients and families.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Analysis of Variance
  • Duodenal Ulcer / blood
  • Duodenal Ulcer / genetics
  • Genes, Dominant*
  • Genetic Variation*
  • Humans
  • Pedigree
  • Pepsinogens / blood
  • Pepsinogens / genetics*


  • Pepsinogens