Influence of native and randomized peanut oil on lipid metabolism and aortic sudanophilia in the vervet monkey

Atherosclerosis. 1982 Mar;42(1):53-8. doi: 10.1016/0021-9150(82)90125-3.


Vervet monkeys (Cercopithecus aethiops pygerethrus) were fed cholesterol-free, semipurified diets containing 40% sucrose, 25% casein, 15% cellulose and 14% peanut oil (PNO), randomized peanut oil (RPNO) or corn oil (CO). After 4 months, serum cholesterol and triglyceride levels, serum lecithin-cholesterol acyl transferase (LCAT) activity and plasma lipoprotein lipase (LPL) activity were similar in all groups. Livers of monkeys fed CO converted 156% more acetate and 24% more mevalonate to cholesterol than those of monkeys fed RPNO. Cholesterogenesis in RPNO-fed monkeys was enhanced compared to PNO (68% from acetate; 62% from mevalonate). Incidence of atherosclerosis was 33% in monkeys fed RPNO, 80% in those fed CO and 90% in those fed PNO. Extent of sudanophilia was lowest in aortas of monkeys fed RPNO. Incidence of arteriosclerosis was 40% in monkeys fed CO, 56% in those fed RPNO and 70% in those fed PNO. Extent of aortic surface showing arteriosclerosis was highest in monkeys fed RPNO.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Aorta / analysis
  • Arteriosclerosis / etiology*
  • Chlorocebus aethiops
  • Cholesterol / biosynthesis*
  • Cholesterol / blood
  • Corn Oil
  • Dietary Fats / adverse effects*
  • Lipid Metabolism*
  • Liver / analysis
  • Oils / adverse effects*
  • Peanut Oil
  • Phosphatidylcholines / blood
  • Plant Oils*
  • Random Allocation
  • Triglycerides / blood


  • Dietary Fats
  • Oils
  • Peanut Oil
  • Phosphatidylcholines
  • Plant Oils
  • Triglycerides
  • Corn Oil
  • Cholesterol