Pharmacokinetics of Teniposide (VM26) and etoposide (VP16-213) in children with cancer

Cancer Chemother Pharmacol. 1982;7(2-3):147-50. doi: 10.1007/BF00254537.


The clinical pharmacokinetics of VM26 and VP16-213 were assessed in 15 children (median age 10 years) with acute leukemia, using a new high-performance liquid chromatography-electrochemical assay. Pharmacokinetic parameters were calculated by both model-dependent and compartment model-independent methods. These studies demonstrated substantial differences in the central volumes of distribution (VDc), steady-state volumes of distribution (VDss) and systemic clearances (Cls) of VM26 and VP16-213; with the VDc, VDss, and Cls all being smaller for VM26, Systemic clearances determined by model-independent methods were 5.2 +/- 1.0 ml/min/m2 (mean +/- SD) for VM26 and 17.8 +/- 11.2 ml/min/m2 for VP16-213. The major metabolites. detected in serum and urine were the hydroxy acids. Low levels of the picro-lactone isomers were detected in some patients while the aglycones were not detected in the serum or urine of any patients.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biotransformation
  • Child
  • Chromatography, High Pressure Liquid
  • Etoposide / metabolism*
  • Humans
  • Kinetics
  • Leukemia / metabolism
  • Models, Biological
  • Neoplasms / metabolism*
  • Podophyllotoxin / analogs & derivatives*
  • Teniposide / metabolism*


  • Etoposide
  • Teniposide
  • Podophyllotoxin