Granulomatous hepatitis and cholangitis associated with giardiasis

Gastroenterology. 1982 Aug;83(2):480-3.


Biopsy of the liver revealed granulomas in portal tracts and cholangitis in a woman with chronic diarrhea, weight loss, fever, hypoalbuminemia, and anemia attributed to giardiasis. Eradication of Giardia resulted in rapid improvement of symptoms and resolution of histologic changes on a second biopsy of the liver after 3 mo. The patient had serum immunoglobulin levels that were either normal (IgG, IgM) or elevated (IgA), detectable levels in serum of anti-Giardia antibody, and an HLA phenotype (B12, B27) known to be associated with prolonged giardiasis.

Publication types

  • Case Reports

MeSH terms

  • Antibodies / analysis
  • Female
  • Giardiasis / complications*
  • Giardiasis / drug therapy
  • Giardiasis / immunology
  • Granuloma / etiology*
  • Granuloma / pathology
  • HLA Antigens / analysis
  • Hepatitis / etiology*
  • Hepatitis / pathology
  • Humans
  • Immunoglobulin A / analysis
  • Liver / pathology
  • Metronidazole / therapeutic use
  • Middle Aged
  • Phenotype


  • Antibodies
  • HLA Antigens
  • Immunoglobulin A
  • Metronidazole